货号：AB4246

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C-C Chemokine Receptor 9 Antibody, C-terminal domain | AB4246 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human CCR9. The specificity of this antibody has been confirmed by IHC staining of human thymus lymphocytes. View All» Epitope: C-terminal domain View All» Immunogen: Synthetic peptide corresponding to a sequence within the C-terminal domain of human CCR9. The immunogen sequence is 100% identical in mouse and rat. View All» Background Information: CCR9, a chemokine receptor, is expressed in thymocytes and T lymphocytes from the small intestine and colon but not in lymphocytes from tonsils, lung, inflamed liver, normal or inflamed skin, inflamed synovium and synovial fluid, breast milk, and seminal fluid (Kunkel et al., 2000). CCR9 is not detected in natural killer cells, monocytes, eosinophils, basophils, and neutrophils. CCR9 binds TECK (thymus-expressed chemokine), a CC chemokine expressed in thymus and small intestine. TECK chemoattracts dendritic cells, thymocytes, and activated macrophages. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry (formalin-fixed paraffin-embedded tissues) Optimal working dilutions must be determined by the end user. View All» Presentation: Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide View All» Storage Conditions: Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P51686 View All» Entrez Gene Number:

• NM_006641.2

• NM_031200.1
  View All» Gene Symbol:
  • CCR9

  • GPR28

  • CC-CKR-9

  • D6

  • GPR-9-6

  • CDw199

  • CCR10

  • CCR-9

  • CMKBR9

  • CCBP2
    View All» Alternate Names: CCR9 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. View All» UniProt Summary: FUNCTION: SwissProt: P51686 # Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.SIZE: 369 amino acids; 42016 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Highly expressed in the thymus and low in lymph nodes and spleen.SIMILARITY: SwissProt: P51686 ## Belongs to the G-protein coupled receptor 1 family.MISCELLANEOUS: EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2. View All» Brand Family: Chemicon View All» Product Name: Anti-C-C Chemokine Receptor 9 Antibody, C-terminal domain | AB4246 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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