货号：AB4240

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C-C Chemokine Receptor 1 Antibody, 2nd extracellular domain | AB4240 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human CCR1. The specificity of this antibody has been confirmed by IHC staining of human spleen lymphocytes. View All» Epitope: 2nd extracellular domain View All» Immunogen: Synthetic peptide corresponding to a sequence within the 2nd extracellular domain of human CCR1. The immunogen has 85% homology with mouse and 80% homology with rat. View All» Background Information: CCR1, a chemokine receptor, affects stem cell proliferation and mediates systemic inflammatory responses. This receptor is stimulated by the beta chemokines RANTES, MCP-1, and MIP-1 alpha. Disruption of CCR1 enhances protection from pulmonary inflammation and reduces the development of respiratory distress syndrome in rat. CCR1 is widely expressed, particularly in hematopoietic cells from blood, vessels, and bone marrow. This receptor has also been reported to be expressed in lung, brain, placenta, heart, skeletal muscle, and kidney. ESTs have been isolated from blood, kidney, liver/spleen, lung, placenta, uterus, and vessel libraries. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry (formalin-fixed paraffin-embedded tissues) Optimal working dilutions must be determined by the end user. View All» Presentation: Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide View All» Storage Conditions: Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P32246 View All» Entrez Gene Number: NM_001295.2 View All» Gene Symbol:

• CCR1

• CC-CKR-1

• HM145

• CCR-1

• MIP1aR

• MIP-1alpha-R

• SCYAR1

• RANTES-R

• CMKR1

• CKR-1

• CD191

• CMKBR1
  View All» Alternate Names: CCR1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. View All» UniProt Summary: FUNCTION: SwissProt: P32246 # Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.SIZE: 355 amino acids; 41173 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Widely expressed in different hematopoietic cells.SIMILARITY: SwissProt: P32246 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-C-C Chemokine Receptor 1 Antibody, 2nd extracellular domain | AB4240 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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