货号：AB4237

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR3 Antibody | AB4237 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human TLR3 (Toll-Like Receptor 3) View All» Immunogen: Synthetic peptide corresponding to amino acids 41-54 of human TLR3. View All» Background Information: TLR3 (Toll-like Receptor 3) is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1 μg/mL Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS with 2% sucrose and 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O15455 View All» Entrez Gene Number: NM_003265.2 View All» Gene Symbol:

• TLR3

• CD283
  View All» Alternate Names: Toll-like Receptor 3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. View All» UniProt Summary: FUNCTION: SwissProt: O15455 # Participates in the innate immune response to microbial agents. May be involved in the recognition of ds-RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).SIZE: 904 amino acids; 103829 Da SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.SIMILARITY: SwissProt: O15455 ## Belongs to the Toll-like receptor family. & Contains 22 LRR (leucine-rich) repeats. & Contains 1 TIR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TLR3 Antibody | AB4237 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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