货号:AB3886
品牌:Merck Millipore
规格:
目录价:¥4146.00
市场价格:¥3524.10
会员价格:¥3316.80
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Description:
Anti-Arp2 Antibody | AB3886
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Trade Name:
Chemicon (Millipore)
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Specificity:
Recognizes Arp2 (Actin-related protein 2). Arp2 belongs to the Arp2/3 complex, which, when stimulated by WASp/Scar proteins, nucleates actin polymerization from the sides of pre-existing actin filaments. The evolutionarily conserved Arp2/3 complex includes Arp2, Apr3, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc.
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Immunogen:
Synthetic peptide corresponding to amino acids 320-341 of human Arp2. The immunogen sequence is 100% identical in mouse, rat, Xenopus, and chicken.
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Species Reactivity:
Human
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Application Notes:
Western blot: 1:1,000-1:2,000 (0.5-1.0 μg/mL). Optimal working dilutions must be determined by end user.
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Presentation:
Affinity purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative.
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Storage Conditions:
Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt.
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UniProt Number:
P61160
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Entrez Gene Number:
-
NM_001005386.1
-
NM_005722.2
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Gene Symbol:
-
ACTR2
-
ARP2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
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Entrez Gene Summary:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: P61160 # Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.SIZE: 394 amino acids; 44761 Da SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.SIMILARITY: SwissProt: P61160 ## Belongs to the actin family. ARP2 subfamily.
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Brand Family:
Chemicon
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Product Name:
Anti-Arp2 Antibody | AB3886
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Concentration:
1.0 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 µg
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Target / Localization:
Most neurons
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Format:
Affinity Purified
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Host:
Rabbit
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