货号：AB3856

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-UbcH3 Antibody | AB3856 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes UbcH3 (Cdc34). View All» Immunogen: Full length, highly purified, UbcH3 protein. View All» Background Information: UbcH3 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunit Cul1 to degrade the NF-kB inhibitor IkBa in a phosphorylation-dependent manner. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:100-1:1000 Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in PBS, pH 7.4. View All» Storage Conditions: Maintain at -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. May be stored at 2-8°C for up to 1 month. View All» UniProt Number: P49427 View All» Entrez Gene Number: NM_004359.1 View All» Gene Symbol:

• CDC34

• UBE2R1

• UBC3

• E2-CDC34

• EC 6.3.2.19
  View All» Alternate Names: Cdc34 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. View All» UniProt Summary: FUNCTION: SwissProt: P49427 # Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin.SIZE: 236 amino acids; 26737 Da SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. When phosphorylated, interacts with beta-TrCP (BTRC).SIMILARITY: SwissProt: P49427 ## Belongs to the ubiquitin-conjugating enzyme family. View All» Brand Family: Chemicon View All» Product Name: Anti-UbcH3 Antibody | AB3856 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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