货号：AB3796

品牌：Merck Millipore

规格：50UL

目录价：￥4285.00

市场价格：￥3642.25

会员价格：￥3428.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-5'-Lipoxygenase Antibody | AB3796 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: 5'-Lipoxygenase View All» Immunogen: Purified human 5'-Lipoxygenase View All» Background Information: 5'-Lipoxygenase is a critical enzyme in the formation of leukotrienes from arachidonic acid. Upon activation, the enzyme translocates to either a nuclear or plasma membrane compartment. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rabbit
  View All» Application Notes: Western blot: 1:1,000. Reacts with a 79 kDa band Immunoprecipitation: 5 μL/mL lysate ELISA: 1:1000 – 1:100,000Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: placenta, lung, and leukocytes. View All» Presentation: Purified immunoglobulin in PBS with 50% Glycerol and 0.02% sodium azide View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P09917 View All» Entrez Gene Number: NM_000698.2 View All» Gene Symbol:
  • ALOX5

  • 5-lipoxygenase

  • 5LPG

  • MGC163204

  • LOG5

  • 5-LO

  • EC 1.13.11.34
    View All» Alternate Names: Arachidonate 5-lipoxygenase; 5-LO View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. View All» UniProt Summary: COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 2 calcium ions per subunit (By similarity).SIZE: 674 amino acids; 77983 Da SUBCELLULAR LOCATION: Cytoplasm; Peripheral membrane protein. Note=Calcium binding promotes binding to membranes.PTM: Serine phosphorylation of LOX5 by MAPKAPK2 is stimulated by arachidonic acid. Serine phosphorylation of LOX5 on Ser-523 by PKA has an inhibitory effect.SIMILARITY: SwissProt: P09917 ## Belongs to the lipoxygenase family. & Contains 1 PLAT domain. View All» Brand Family: Chemicon View All» Product Name: Anti-5'-Lipoxygenase Antibody | AB3796 View All» Concentration: 100 μg/150 μL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Rabbit View All»
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