货号：AB3737

品牌：Merck Millipore

规格：

目录价：￥4212.00

市场价格：￥3580.20

会员价格：￥3369.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RBX1 Antibody | AB3737 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: AB3737 recognizes human RBX1. View All» Molecular Weight: ~12 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated synthetic peptide corresponding to amino acids 94-108 within the C-terminus of human RBX1. View All» Background Information: RING-box protein 1 RBX1 is an evolutionarily conserved protein that interacts with cullins. It plays a unique role in the ubiquitination reaction by forming a heterodimer with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over. RBX1 is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, RBX1 seems to recruit the E2 ubiquitination enzyme CDC34 to the complex and brings it into close proximity to the substrate and probably stimulates CDC34 autoubiquitination. It promotes the neddylation of CUL1 and probably CUL2. RBX1 may be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Zebrafish
  View All» Species Reactivity Note: Human. Predicted to cross react with mouse, rat, and zebrafish, based on sequence homology Reactivity with other species has not been tested. View All» Control: Human testis lysate View All» Quality Assurance: Routinely evaluated by Western blot on human testis lysate using 0.5 g/mL of Anti-RBX1 at 0.5 mg/mL. View All» Purification Method: Peptide affinity purified View All» Presentation: Purified in PBS containing 0.09% NaN3 View All» Storage Conditions: Maintain at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: P62877 View All» Entrez Gene Number: NM_014248 View All» Gene Symbol:
  • BA554C12.1

  • MGC13357

  • MGC1481

  • OTTHUMP00000028983

  • RNF75

  • ROC1

  • Rbx1
    View All» Alternate Names:
    • Protein ZYP

    • RING box protein 1

    • RING finger protein

    • RING finger protein 75

    • Regulator of cullins

    • ZYP protein

    • ring-box 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. Promotes the neddylation of CUL1 and probably CUL2. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interacts with CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. DOMAIN: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion. View All» Product Name: Anti-RBX1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-153512.htm
      © Merck Millipore代理AB3737 Anti-RBX1 (rabbit polyclonal)，产品报价联系微信jinshanbio