货号：AB3632

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Livin View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the N-terminus of the Livin protein. View All» Immunogen: Synthetic peptide View All» Background Information: Livin is a novel inhibitor of apoptosis. Disruption of Livin function induces apoptosis in certain cancer cells. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500-1:1000 Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS, containing 0.02% sodium azide. View All» Storage Conditions: Maintain at 2-8ºC for up to 3 months. For longer storage, aliquot and freeze at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q96CA5 View All» Entrez Gene Number:

• NM_022161.2

• NM_139317.1
  View All» Gene Symbol:
  • BIRC7

  • LIVIN

  • ML-IAP

  • MLIAP

  • mliap

  • KIAP

  • RNF50

  • Livin
    View All» Alternate Names: Baculoviral IAP Repeat-containing Protein 7; KIAP; ML-IAP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. View All» UniProt Summary: FUNCTION: SwissProt: Q96CA5 # Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine- induced apoptosis and isoform 2 blocks etoposide-induced apoptosis.SIZE: 298 amino acids; 32798 Da SUBUNIT: Binds to caspase-9. Interaction with SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm.TISSUE SPECIFICITY: Very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines (isoform 1 and isoform 2). Isoform 2 (but not isoform 1) is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.SIMILARITY: SwissProt: Q96CA5 ## Belongs to the IAP family. & Contains 1 BIR repeat. & Contains 1 RING-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-Livin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-153486.htm
    © Merck Millipore代理AB3632 LIVIN, RBX-100UG；该产品已停产，产品报价联系微信jinshanbio