货号：AB3615

品牌：Merck Millipore

规格：50Ug

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-cIAP-2 Antibody | AB3615 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human and mouse cIAP-2. A member of the Inhibitors of Apoptosis (IAP) proteins, cIAP-2 contains a BIR (baculovirus IAP repeat) domain near the amino-terminus. This BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and 7. XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms. View All» Immunogen: Synthetic peptide toward the C - terminal end of cIAP-2 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:200 Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide. View All» Storage Conditions: Maintain at -20°. For long term storage, aliquot and freeze at -70°. View All» UniProt Number: Q13489 View All» Entrez Gene Number:
  • NM_001165.3

  • NM_182962.1
    View All» Gene Symbol:
    • BIRC3

    • RNF49

    • MALT2

    • MIHC

    • HAIP1

    • hiap-1

    • C-IAP2

    • API2

    • HIAP1

    • HIAP-1

    • AIP1

    • IAP1

    • CIAP2

    • cIAP2
      View All» Alternate Names: cIAP; HIAP1; IAP homolog C; API2; BIRC3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q13489 # Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).SIZE: 604 amino acids; 68372 Da SUBUNIT: Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.SUBCELLULAR LOCATION: Cytoplasm (Potential).TISSUE SPECIFICITY: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.DISEASE: SwissProt: Q13489 # A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.SIMILARITY: SwissProt: Q13489 ## Belongs to the IAP family. & Contains 3 BIR repeats. & Contains 1 CARD domain. & Contains 1 RING-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-cIAP-2 Antibody | AB3615 View All» Concentration: 0.2 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rabbit View All»
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