货号：AB3553

品牌：Merck Millipore

规格：50UL

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Thiazide-Sensitive NaCl Cotransporter Antibody | AB3553 View All» Replaces: AB3564P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the renal thiazide-sensitive NaCl cotransporter (NCC). The antibody stains the apical plasma membrane and subapical membrane vesicles in renal distal convoluted tubule cells. View All» Molecular Weight: 160-190 kDa View All» Immunogen: Synthetic peptide from the N-terminal of human/rat/mouse NCC. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rabbit
  View All» Application Notes: Immunoblotting: 1:2,000 using rat kidney extract. The antibody reacts with the 160-190 kDa protein (the molecular weight varies depending on conditions for protein extraction/electrophoresis). The suggested dilution and blocking buffer is 150 mM NaCl, 10 mM Tris, pH 7.4 containing 5% low fat milk and 0.04% Tween. Suggested transfer membrane is PVDF or Nylon. Suggested gel percentage is 7%. Overnight incubation with the antibody at 2-8°C is recommended. Immunohistochemistry: 1:500-1:2,000 on rat or mouse kidney tissue. Suggested fixative is 3% paraformaldehyde for 5 minutes by vascular perfusion. Suggested blocking buffer is PBS containing 10% normal goat serum. Suggested dilution buffer is PBS containing 1% BSA. Overnight incubation with the antibody at 2-8°C is recommended.Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: Rat kidney. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin in PBS containing no preservatives. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P55017 View All» Entrez Gene Number: NM_000339.1 View All» Gene Symbol:
  • SLC12A3

  • NCCT

  • TSC
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P55017 # Electrically silent transporter system. Mediates sodium and chloride reabsorption.SIZE: 1021 amino acids; 113139 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Predominant in kidney.DISEASE: SwissProt: P55017 # Defects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disease characterized by diverse abnormalities in electrolyte homeostasis including hypokalaemic metabolic alkalosis. GS is a subset of Bartter syndrome.SIMILARITY: SwissProt: P55017 ## Belongs to the SLC12A transporter family. View All» Brand Family: Chemicon View All» Product Name: Anti-Thiazide-Sensitive NaCl Cotransporter Antibody | AB3553 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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      © Merck Millipore代理AB3553 Anti-Thiazide-Sensitive NaCl Cotransporter Antibody;抗噻嗪敏感性NaCl协同转运蛋白抗体store at -20℃，产品报价联系微信jinshanbio