货号：AB3543

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hexokinase Type I Antibody | AB3543 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Hexokinase type I. No reactivity with hexokinase types II and III by immunoblotting. Reactivity with type I hexokinase from other mammalian species is expected but has not been confirmed experimentally. View All» Immunogen: Rat hexokinase type I. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:2,000. Recognizes the ~110 kDa protein. Suggested dilution buffer is Tris buffered saline containing 1% Tween 20. Immunohistochemistry on frozen tissue sections: 1:100 using a fluorescent secondary antibody. Suggested dilution buffer is PBS containing 1% normal goat serum. Immunoprecipitation: not tested but the antibody is expected to work well. Optimal working dilutions must be determined by the end user. View All» Control: Positive control: Brain View All» Presentation: Rabbit serum. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P19367 View All» Entrez Gene Number:

• NM_000188.1

• NM_033496.1

• NM_033497.1

• NM_033498.1

• NM_033500.1
  View All» Gene Symbol:
  • HK1

  • HK1-tc

  • HKI

  • HK1-tb

  • HK1-ta

  • Hexokinase-1

  • HXK1

  • EC 2.7.1.1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. View All» UniProt Summary: SIZE: 917 amino acids; 102486 Da SUBUNIT: Monomer.SUBCELLULAR LOCATION: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.TISSUE SPECIFICITY: Isoform 2 is erythrocyte specific; isoform 3 and isoform 4 are testis-specific.DOMAIN: SwissProt: P19367 The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.DISEASE:SwissProt: P19367 # Defects in HK1 are the cause of hexokinase deficiency [MIM:235700]. Hexokinase deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.SIMILARITY: Belongs to the hexokinase family.MISCELLANEOUS: In vertebrates there are four major glucose- phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase)." View All» Brand Family: Chemicon View All» Product Name: Anti-Hexokinase Type I Antibody | AB3543 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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