货号：AB3530P

品牌：Merck Millipore

规格：50Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Epithelial Sodium Channel-α Antibody | AB3530P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes rat Epithelial Sodium Channel alpha (ENaC alpha). The immunogen shows no significant sequence homology with other ENaC subunits. View All» Molecular Weight: 83-90kDa View All» Immunogen: A 20 amino acid peptide sequence near the N-terminus of rat ENaC alpha (Linguela et al. 1993; Canessa et al. 1993; Snyder et al. 1994; Waldmann et al. 1995; Kreutz et al. 1997; Voilley et al. 1994; McDonald et al. 1994; Ludwig et al. 1998; Garty & Palmer 1997). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-10 μg/mL using ECL and rat brain membrane preparations, see membrane preparation protocol under Technical Support\General Technical Info\General Methods at www.chemicon.com. 83-90kDa band is expected. Optimal working dilutions must be determined by the end user. View All» Control: Epithelial structures View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P37088 View All» Entrez Gene Number: NM_001038.4 View All» Gene Symbol:

• SCNN1A

• SCNEA

• FLJ21883

• ENaCa

• SCNN1

• Alpha-ENaC

• Alpha-NaCH

• ENaCalpha
  View All» Alternate Names: ENaC-alpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P37088 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.SIZE: 669 amino acids; 75704 Da SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.TISSUE SPECIFICITY: Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.PTM: Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).DISEASE: SwissProt: P37088 # Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss.SIMILARITY: SwissProt: P37088 ## Belongs to the amiloride-sensitive sodium channel family. View All» Brand Family: Chemicon View All» Product Name: Anti-Epithelial Sodium Channel-α Antibody | AB3530P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Target / Localization: Surface of many epithelial taste and renal tubule cells View All» Format: Affinity Purified View All» Host: Rabbit View All»
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