货号：AB3467

品牌：Merck Millipore

规格：

目录价：￥4891.00

市场价格：￥4157.35

会员价格：￥3912.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Methyl-CpG Binding Domain Protein 2, Isoform 1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Methyl-CpG binding domain protein 2 isoform 1 (MBD2) View All» Immunogen: Human MBD2, amino acids 11-27. View All» Species Reactivity: Human View All» Application Notes: ELISA, direct: 0.1-5.0 μg/mL It is expected that the antibody will also work for Western blot, immunocytochemistry and immunohistochemistry. Specific reactivity has not been confirmed. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9UBB5 View All» Entrez Gene Number:

• NM_003927.3

• NM_015832.3
  View All» Gene Symbol:
  • MBD2

  • DKFZp586O0821

  • Demethylase

  • NY-CO-41

  • DMTase
    View All» Alternate Names: MBD2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: ELISA View All» Entrez Gene Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. View All» UniProt Summary: FUNCTION: SwissProt: Q9UBB5 # Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory.SIZE: 411 amino acids; 43255 Da SUBUNIT: Heterodimer with MBD3. Part of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, XAB1, SIN3A, p66- alpha and p66-beta. Isoform 1 binds DHX9, but isoform 2 does not.SUBCELLULAR LOCATION: Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.TISSUE SPECIFICITY: Highly expressed in brain, heart, kidney, stomach, testis and placenta.SIMILARITY: SwissProt: Q9UBB5 ## Contains 1 MBD (methyl-CpG-binding) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Methyl-CpG Binding Domain Protein 2, Isoform 1 View All» Concentration: 0.89 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Chicken View All»
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