货号：AB3429

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DNA Methyltransferase 1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: DNMT1 (DNA methyltransferase 1) View All» Immunogen: Human DNMT1, amino acids 177-550. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500-1:2,000 (colormetric) It is expected that the antibody will also work for immunohistochemistry and immunocytochemistry. Specific reactivity has not been confirmed. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P26358 View All» Entrez Gene Number: NM_001379.1 View All» Gene Symbol:

• DNMT1

• Dnmt1

• FLJ16293

• AIM

• DNMT

• CXXC9

• M.HsaI

• DNA

• MCMT

• MGC104992

• EC 2.1.1.37
  View All» Alternate Names: Dnmt1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. View All» UniProt Summary: FUNCTION: SwissProt: P26358 # Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.SIZE: 1616 amino acids; 183165 Da SUBUNIT: Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.SIMILARITY: SwissProt: P26358 ## Belongs to the C5-methyltransferase family. & Contains 2 BAH domains. & Contains 1 CXXC-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-DNA Methyltransferase 1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Chicken View All»
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