货号：AB3245

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody | AB3245 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Topoisomerase (DNA) II Binding Protein 1 (TopBP1). SPECIES REACTIVITIES: Other species have not been tested. View All» Immunogen: Synthetic peptide corresponding to a portion of human TopBP1 encoded within exon 29. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000-1:10,000 Immunoprecipitation: 0.5 to 2.5 μL Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate, pH 7-8 containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted for up to 6 months after date of receipt. View All» UniProt Number: Q92547 View All» Entrez Gene Number: NM_007027.2 View All» Gene Symbol:

• TOPBP1

• TOP2BP1

• TopBP1

• KIAA0259
  View All» Alternate Names: TopBP1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. View All» UniProt Summary: FUNCTION: SwissProt: Q92547 # Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.SIZE: 1522 amino acids; 170679 Da SUBUNIT: Binds EDD, E2F1, PML, RAD9A, SMARCA2, SMARCA4 and POLE. May interact with TOP2B.SUBCELLULAR LOCATION: Nucleus. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.TISSUE SPECIFICITY: Highly expressed in heart, brain, placenta, lung and kidney.PTM: Phosphorylated on serine and threonine residues in response to X-ray irradiation. & Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.SIMILARITY: SwissProt: Q92547 ## Contains 8 BRCT domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody | AB3245 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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