货号：AB3242

品牌：Merck Millipore

规格：100UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PGC-1 Antibody | AB3242 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for PGC-1 (PPARγ Coactivator 1). No cross reactivity with other proteins detected. The antibody binding has been inhibited by pre-incubating the antibody with the peptide immunogen. View All» Molecular Weight: 100 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide from amino acids 777-797 (C-terminus) of mouse PGC-1 View All» Background Information: PGC-1 is a transcription factor that determines whether preadipocytes will differentiate into brown or white fat cells. It interacts with PPARgamma to promote the expression of a cassette of genes which define the brown adipocyte phenotype. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Mouse. It is expected that this antibody will also react with human due to sequence homology. View All» Application Notes: Immunocytochemistry: A 1:300 dilution of a previous lot was used in Immunocytochemistry.ELISA: A 1:75,000 dilution of a previous lot was used in ELISA.Optimal working dilutions must be determined by end user. View All» Control: BAT nuclear prep View All» Quality Assurance: Western blot: A 1:1,000 dilution of this antibody was used in Western Blot. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 20 mM PBS and 0.1% sodium azide. View All» Storage Conditions: Stable for 1 year at -80ºC from date of receipt. View All» UniProt Number: O70343 View All» Entrez Gene Number: NM_008904.1 View All» Gene Symbol:
  • PPARGC1A

  • PPARGC-1-alpha

  • PPARGC1

  • PGC-1-alpha

  • PGC1A

  • PGC-1(alpha)

  • LEM6

  • PGC1

  • PGC-1v
    View All» Alternate Names: PPARgamma Coactivator 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. View All» UniProt Summary: FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.SIZE: 797 amino acids; 90,588 Da SUBUNIT: Binds MYBBP1A, which inhibits transcriptional activation by this protein (By similarity). Interacts with LRPPRC. Homooligomer.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Brown adipose tissue, heart, kidney and brain.SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-PGC-1 Antibody | AB3242 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μl View All» Format: Affinity Purified View All» Host: Rabbit View All»
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