货号：AB3208

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/HCO3- Cotransporter Antibody, a.a. 928-1035 | AB3208 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the Na+/HCO3 Cotransporter (NBC) within the C-terminus a.a. 928-1035. Reacts with kidney, brain, pancreas, stomach and intestine. This antigenic sequence is not present in some NBC isoforms, e.g. in the rat aorta form of NBC. In Western blot the antibody recognizes a major band of approximately 130 kDa in rat and rabbit and a major band of approximately 160 kDa in salamander kidney. View All» Epitope: a.a. 928-1035 View All» Immunogen: Fusion protein of MBP with a.a. 928-1035 of rat kidney Na+/HCO3 Cotransporter (rkNBC; Romero et al., Nature 387:409-413, 1997). View All» Species Reactivity:

• Human

• Rat

• Rabbit

• Salamander
  View All» Application Notes: Immunohistochemistry: 1:100 on PLP fixed tissues sections. Immunocytochemistry: 1:100 on HEK-293 cells. Western blot: 1:500-1:1,000. Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y6R1 View All» Entrez Gene Number:
  • NM_001098484.1

  • NM_003759.2
    View All» Gene Symbol:
    • SLC4A4

    • +HCO3

    • KNBC

    • NBCE1

    • pNBC

    • NBC

    • -cotransporter)

    • NBC2

    • NBC1

    • HHNMC

    • hhNMC

    • kNBC1

    • HNBC1

    • SLC4A5

    • Na

    • DKFZp781H1314
      View All» Alternate Names: NBC View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) [PubMed 10099707] reviewed NBCs. Soleimani and Burnham (2000) [PubMed 10652014] reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9Y6R1 # Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.SIZE: 1079 amino acids; 121461 Da SUBUNIT: Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity.SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.PTM: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylation of Thr-49 regulates isoform 1 conductance. & N-glycosylation is not necessary for the transporter basic functions.DISEASE: "SwissProt: Q9Y6R1 # Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities [MIM:604278]; also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. PRTA with ocular abnormalities is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy."SIMILARITY: SwissProt: Q9Y6R1 ## Belongs to the anion exchanger (TC 2.A.31) family.MISCELLANEOUS: Loss of interaction and stimulation by CA4 is the cause of retinitis pigmentosa 19 (RP19)." View All» Brand Family: Chemicon View All» Product Name: Anti-Na+/HCO3- Cotransporter Antibody, a.a. 928-1035 | AB3208 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-153208.htm
        © Merck Millipore代理AB3208 SODIUM BICARB TRANS, RBX-100UL;已停产，产品报价联系微信jinshanbio