货号：AB3121

品牌：Merck Millipore

规格：50Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Angiopoietin-2 Antibody, N-terminus | AB3121 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mouse Angiopoietin-2 (Ang-2). Mouse/human Ang-2 is a 496 AA secreted angiogenic protein (Suri et al. 1996). There is ~85% homology between mouse and human Ang-2. It is only 60% homologous with Ang-1 (Davis et al. 1996). Ang-2 may act as an antagonist of Ang-1 and Tie-2 (Suri et al. 1996). It is prominently expressed in tissues that are in involved in vascular remodeling (ovary, placenta, and uterus). The immunogenic peptide sequence is 71% (15/21 aa) homologous with human Ang-2 and has no substantial homology with Ang-1. Antibody crossreactivity in other species is not established. The immunogen peptide is 85% conserved in porcine and 55% in chicken. View All» Epitope: N-terminus View All» Immunogen: 20 amino acid peptide sequence near the amino-terminus of mouse Ang-2. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1-10 μg/mL using ECL. The predicted size of Ang-2 is ~55 kDa. Like Ang-1, its size may higher due to glycosylation. ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide per well. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin presented as liquid in PBS containing 0.1% BSA and 0.05% azide, pH 7.5 View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O15123 View All» Entrez Gene Number: NM_001147.1 View All» Gene Symbol:

• ANGPT2

• ANG-2

• Tie2-ligand

• ANG2

• angiopoietin-2a

• AGPT2

• Ang2

• angiopoietin-2B

• angiopoietin-2
  View All» Alternate Names: Ang-2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: O15123 # Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.SIZE: 496 amino acids; 56919 Da SUBCELLULAR LOCATION: Secreted.SIMILARITY: SwissProt: O15123 ## Contains 1 fibrinogen C-terminal domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Angiopoietin-2, N-terminus View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Target / Localization: early marker of the renal pericyte and vascular smooth muscle lineage View All» Format: Affinity Purified View All» Host: Rabbit View All»
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