R&D Systems代理E2-664-100 Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex, CF (100 UG)-试剂-金山科研平台

R&D Systems代理E2-664-100 Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex, CF (100 UG)

2025-06-29

货号：E2-664-100

品牌：R&D Systems

规格：100ug

目录价：￥3130.00

市场价格：￥2504.00

会员价格：￥2504.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Contains an terminal 6-His tag Accession #:P61088 (UBE2N) & Q13404 (Uev1a) Purity:>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain. Predicted Molecular Mass:

18 kDa (UBE2N) & 21kDa(Uev1a)

Activity:Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex concentration of 0.1-1 µM. Formulation:Supplied as a solution in HEPES, NaCl, DTT and Glycerol.See Certificate of Analysis for details. Molecule Information: UBE2N (Ubc13)/Uev1a Complex Entrez Gene IDs: 7334 (Human) Background: UBE2N (Ubc13)/Uev1a Complex Ubiquitin-conjugating Enzyme E2N (UBE2N), also known as Ubiquitin-conjugating Enzyme 13 (Ubc13), forms a functional complex with the catalytically inactive Uev1a/UBE2V1 protein. Human UBE2N/Ubc13 shares 100% and 99% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. Human Uev1a/UBE2V1 shares 89% aa sequence identity with its mouse and rat orthologs. The UBE2N (Ubc13)/Uev1a Complex functions with Ubiquitin ligases (E3s), including TRAF-6 and TRIM5, to synthesize Lys63-linked Ubiquitin chains. These Ubiquitin chains can either be unanchored or attached to target proteins. The UBE2N (Ubc13)/Uev1a Complex localizes primarily to the cytoplasm and is important for NF-kappa B activation. Additionally, this complex may function in the intracellular response to retroviral capsid recognition. Pathologically, the UBE2N (Ubc13)/Uev1a Complex is required for the proliferation of diffuse large B-cell lymphoma cells, suggesting that it may play a role in cancer.

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