货号：AB3040

品牌：Merck Millipore

规格：50Ug

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Uncoupling Protein 2 Antibody | AB3040 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Uncoupling Protein 2 (UCP2), mouse. Mouse UCP2 is a 309 amino acid mitochondrial uncoupling protein (Fleury et al. 1997). It is only 59% homologous with UCP1 found in brown adipose tissues. Mouse UCP2 (chromosome 7) has approximately 95% homology with human UCP2 located on chromosome 11 (Fleury et al. 1997). UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation (Fleury et al. 1997; Flier & Lowell 1997). SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology in rat, 86% homology in human, porcine, canine and bovine. View All» Immunogen: 14 aa peptide sequence near the C-terminus of the mouse UCP2 (Fleury et al. 1997). The peptide has no significant homology with UCP1 or UCP3 (Boss et al. 1997). This peptide is available for blocking as catalog number AG788. View All» Species Reactivity: Mouse View All» Application Notes: Western Blotting: 1-10 μg/mL using Chemiluminescence technique. ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS, pH 7.4 with 0.1% BSA as stabilizer and 0.02% sodium merthiolate. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P55851 View All» Entrez Gene Number: NM_003355.2 View All» Gene Symbol:

• UCP2

• UCPH

• SLC25A8
  View All» Alternate Names: UCP2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. View All» UniProt Summary: FUNCTION: SwissProt: P55851 # UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.SIZE: 309 amino acids; 33229 Da SUBUNIT: Acts as a dimer forming a proton channel (By similarity).SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.SIMILARITY: SwissProt: P55851 ## Belongs to the mitochondrial carrier family. & Contains 3 Solcar repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Uncoupling Protein 2 Antibody | AB3040 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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