货号：AB3000

品牌：Merck Millipore

规格：50UL

目录价：￥3977.00

市场价格：￥3380.45

会员价格：￥3181.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IP3 Receptor Type II Antibody | AB3000 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Rabbit anti-Type II Inositol 1,4,5-Trisphosphate Receptor (IP3R) is directed against a synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor. The antibody is reactive with Type II IP3R from rat, mouse, human, hamster, and monkey. View All» Immunogen: Synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor View All» Species Reactivity:

• Human

• Hamster

• Mouse

• Monkey

• Rat
  View All» Application Notes: Western blot: 1:50 - 1:100 (detects a 260 kDa band) Immunofluorescence: 1:10 - 1:20 Immunoprecipitation Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines. Immunohistochemistry: Paraformaldehyde or methanol fixes are effective. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified versus immobilized immunogen peptide. Liquid in PBS buffer, containing 0.05% BSA, 10% glycerol, 0.005% sodium azide. Caution: Sodium azide is hazardous. MSDS available upon request. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q14571 View All» Entrez Gene Number: NM_002223.2 View All» Gene Symbol:
  • ITPR2

  • InsP3R2

  • IP3R2
    View All» Alternate Names: Inositol 1,4,5-Trisphosphate Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunofluorescence

    • Immunohistochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q14571 # Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.SIZE: 2701 amino acids; 308078 Da SUBUNIT: Homotetramer (By similarity).SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: The short isoform is found in skeletal muscle and heart.DOMAIN: SwissProt: Q14571 The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.PTM: Phosphorylated on tyrosine residues (By similarity).SIMILARITY: Belongs to the InsP3 receptor family. & Contains 5 MIR domains. MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor. View All» Brand Family: Chemicon View All» Product Name: Anti-IP3 Receptor Type II Antibody | AB3000 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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