货号：AB2980

品牌：Merck Millipore

规格：EA

目录价：￥3760.00

市场价格：￥3196.00

会员价格：￥3008.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tricellulin Antibody | AB2980 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes the C-terminus of Tricellulin. View All» Molecular Weight: UniProtKB/Swiss-Prot entry Q8N4S9 describes 3 isoforms produced by alternative splicing: Isoform 1 at 64 kDa, Isoform 2 at 511kDa, and Isoform 3 at 63 kDa. View All» Epitope: C-terminus View All» Immunogen: Recombinant protein corresponding to the C-terminus of human Tricellulin. View All» Background Information: Tricellulin, also known as MARVEL domain-containing protein 2, is a tetraspan transmembrane protein that participates in tight junction formation across cells. Occludin and tricellulin are the only human proteins known to contain both a MARVEL domain and an OCC-ELL domain. As such they are likely to have shared yet disparate functions. This protein is known to be phosphorylated and it’s function is likely to be regulated by it’s phosphorylation status. View All» Species Reactivity:

• Human

• Canine
  View All» Species Reactivity Note: Demonstrated to react with human and canine. Other noted sequence homologies include mouse (94%) and rat (93%). View All» Application Notes: Immunoprecipitation Analysis: 5 µg from a previous lot immunoprecipitated Tricellulin from 1mg of ARPE-19 RIPA lysate.Immunofluorescence Analysis: 1:1,000 dilution from a previous lot detected Tricellulin in MDCK cells. View All» Control: ARPE-19 cell lysate View All» Quality Assurance: Evaluated by Western blot in ARPE-19 cell lysate.Western blot Analysis: 0.1 µg/ml of this antibody detected Tricellulin in 10 µg of ARPE-19 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N4S9 View All» Entrez Gene Number: NP_001033692 View All» Gene Symbol:
  • MARVELD2

  • DFNB49

  • MARVD2

  • MRVLDC2

  • TRIC

  • Tric

  • Tricellulin
    View All» Alternate Names:
    • MARVEL (membrane-associating) domain containing 2

    • MARVEL domain containing 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunofluorescence
        View All» Entrez Gene Summary: Tight junctions (TJ) prevent leakage of solutes through the paracellular pathway of epithelial cells. MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts (Ikenouchi et al., 2005 [PubMed 16365161]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › tight junction By similarity. Note: Found at tricellular contacts By similarity.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. INVOLVEMENT IN DISEASE: Defects in MARVELD2 are the cause of non-syndromic sensorineural deafness autosomal recessive type 49 (DFNB49) [MIM:610153]. DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. SEQUENCE SIMILARITIES: Contains 1 MARVEL domain. View All» Product Name: Anti-Tricellulin View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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