R&D Systems代理E2-616-100 Recombinant Human UbcH5a/UBE2D1 Protein, CF (100 UG)

2025-06-29

货号:E2-616-100

品牌:R&D Systems

规格:100ug

目录价:¥3130.00

市场价格:¥2504.00

会员价格:¥2504.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:E. coli-derived, Accession #:P51668 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain. Predicted Molecular Mass:17 kDa Activity:Recombinant Human UbcH5a/UBE2D1 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human UbcH5a/UBE2D1 concentration of 0.1-1 µM. Formulation:Supplied as a solution in HEPES, NaCl, Glycerol.See Certificate of Analysis for details. Molecule Information: UbcH5a/UBE2D1 Aliases: E2(17)KB1; UBC4/5; UBC5A; UBE2D1 Entrez Gene IDs: 7321 (Human); 216080 (Mouse); 361831 (Rat) Background: Ubch5a Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as Ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively. Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger Ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins. UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate Ubiquitin to the tumor suppressor, p53. Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1. Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses.

    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
    © 本文地址:https://16ao.com/thread-153106.htm
    © R&D Systems代理E2-616-100 Recombinant Human UbcH5a/UBE2D1 Protein, CF (100 UG),产品报价联系微信jinshanbio
  • 产品询价需求提交
    产品询价请加微信:jinshanbio
    返回