货号：AB2965

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TIMP-2 (C-terminus) Antibody | AB2965 View All» Replaces: AB19029 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes TIMP-2 at the C-terminus. View All» Molecular Weight: ~ 24 kDa observed. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human TIMP-2. View All» Background Information: Tissue inhibitor of metalloproteinases 2 (TIMP-2) is a member of the protease inhibitor I35 (TIMP) family. TIMP-2 binds with the catalytic zinc cofactors of metalloproteinases, thereby forming a complex and irreversibly activating them. High concentrations of TIMP-2 have been shown to down-regulate progelatinase A activation. TIMP-2 performs a regulatory role for cell proliferation. It interacts with several MMPs including MMP-1 to MMP-3, MMP-7 to MMP-10, MMP-13 to MMP-16, MMP-19, and MT1-MMP. MMP-2 activity is inhibited through interaction with TIMP-2. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Pig

• Horse

• Canine

• Rabbit
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with bovine, porcine, equine, canine, rabbit, and guinea pig based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected TIMP-2 in cervical carcinoma tissue. View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 0.1 µg/mL of the antibody detected TIMP-2 in 10 µg of human kidney tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P16035 View All» Entrez Gene Number: NP_003246 View All» Gene Symbol:
  • TIMP2

  • TIMP-2

  • CSC-21K
    View All» Alternate Names:
    • TIMP metallopeptidase inhibitor 2

    • tissue inhibitor of metalloproteinase 2

    • Tissue inhibitor of metalloproteinases 2

    • metalloproteinase inhibitor 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. SUBUNIT STRUCTURE: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity. SUBCELLULAR LOCATION: Secreted. INDUCTION: Down-regulated by TGFbeta1. PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.SEQUENCE SIMILARITIES: Belongs to the protease inhibitor I35 (TIMP) family. (View classification).Contains 1 NTR domain. View All» Product Name: Anti-TIMP-2 (C-terminus) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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