货号：AB2960

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-UVRAG Antibody | AB2960 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of UVRAG. View All» Molecular Weight: ~78 kDa observed View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human UVRAG. View All» Background Information: UV irradiation resistance-associated gene (UVRAG) is an essential component of the Beclin1-PI(3)KC3 lipid kinase complex which functions as an important signaling checkpoint for autophagy and tumor-cell growth. More specifically, UVRAG seems to work as a multivalent trafficking effector that controls autophagosome formation and maturation, and also controls the engaging of the fusion apparatus to the endosome. UVRAG may be a promising target for cancer therapies. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated UVRAG from 500 µg from Raji cell lysate.Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected UVRAG in NIH/3T3 and A431 cells. View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in Raji cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected UVRAG in 10 µg of Raji cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9P2Y5 View All» Entrez Gene Number: NP_003360 View All» Gene Symbol: UVRAG View All» Alternate Names:
  • UV radiation resistance-associated gene protein

  • p63
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunoprecipitation
      View All» Entrez Gene Summary: Summary: This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq]. View All» UniProt Summary: SUBUNIT STRUCTURE: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition.SUBCELLULAR LOCATION: Late endosome. Lysosome. Early endosome. Note: Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.TISSUE SPECIFICITY: Highly expressed in brain, lung, kidney and liver.INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).SEQUENCE SIMILARITIES: Contains 1 C2 domain.SEQUENCE CAUTION: The sequence CAA67507.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-UVRAG View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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