货号：AB2930

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bax Antibody, a.a. 43-61 hBax | AB2930 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: AB2930 recognizes human Bax protein; sequence used is conserved in alpha, beta, sigma, epsilon, psi isoforms, cross reactivity to other species is untested. View All» Epitope: a.a. 43-61 hBax View All» Immunogen: Peptide against human Bax aa 43-61 View All» Background Information: BAX is one of the pro-apoptotic members of the Bcl-2 family. BAX is assumed to exert at least part of its apoptosis-inducing function by facilitating mitochondrial permeability transition pore opening, a process that is supposedly antagonized by the anti-apoptotic members Bcl-2 and Bcl-XL by the ability to form hetero-dimers. View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: Recommended antibody dilution 1:2000-5000 Immunoprecipitation: Recommended antibody dilution 1:150 Immunohistochemistry: Recommended antibody dilution 1:800; frozen, 4% PFA fixed sections Optimal dilutions must be determined by end-user. View All» Presentation: Whole serum without preservatives. View All» Storage Conditions: Store at -20°C for up to 12 months from date of receipt. Avoid multiple freeze thaws. View All» UniProt Number: Q07814 View All» Entrez Gene Number:

• NM_004324.3

• NM_138761.2

• NM_138763.2

• NM_138764.2

• NM_138765.2
  View All» Gene Symbol: BAX View All» Alternate Names: Bcl-2-associated X Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunoprecipitation

  • Immunohistochemistry
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q07814 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.SIZE: 41 amino acids; 4678 Da SUBUNIT: Interacts with HN.SUBCELLULAR LOCATION: Cytoplasm.DOMAIN: SwissProt: Q07815 DISEASE:SwissProt: Q07812 # Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.SIMILARITY: SwissProt: Q07815 ## Belongs to the Bcl-2 family. | Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. | P55269 ## Belongs to the Bcl-2 family. | Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Bax Antibody, a.a. 43-61 hBax | AB2930 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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