货号：AB2910

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mcl-1 Antibody | AB2910 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Human Mcl-1. Not reactive with other members of the Bcl-2 family, as verified by immunoblot. View All» Immunogen: Synthetic peptide corresponding to amino acids 121-139 of human Mcl-1. View All» Species Reactivity: Human View All» Application Notes: Immunoblot 1:2,000 Immunoprecipitation. Precipitates a 37-39 kDa protein, which appears as a doublet in some cells. Immunohistochemistry (formalin-fixed, paraffin-embedded tissues) The following tissues/cells can serve as positive controls: tonsil, tonsillar B cells, B-cell lines Reh, Daudi, and Karpas 422. Optimal working dilutions for AB2910 must be determined by end user. View All» Presentation: Liquid antiserum. View All» Storage Conditions: Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles. View All» UniProt Number: Q07820 View All» Entrez Gene Number:

• NM_021960.3

• NM_182763.1
  View All» Gene Symbol:
  • MCL1

  • MCL1L

  • mcl1/EAT

  • MGC104264

  • MGC1839

  • TM

  • MCL1S

  • EAT
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. View All» UniProt Summary: FUNCTION: SwissProt: Q07820 # Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.SIZE: 350 amino acids; 37337 Da SUBUNIT: Interacts with BAD, BOK, BIK, BFM and PMAIP (By similarity). Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro- apoptototic BCL2-related proteins.SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.PTM: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. & Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. & Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.SIMILARITY: SwissProt: Q07820 ## Belongs to the Bcl-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Mcl-1 Antibody | AB2910 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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