货号：AB2299

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NR2E3 Antibody | AB2299 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2299 recognizes NR2E3 protein. View All» Molecular Weight: ~44 kDa View All» Epitope: Full Length Protein View All» Immunogen: Full Length Recombinant Protein. View All» Background Information: NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» Species Reactivity:

• Bovine

• Rat

• Human
  View All» Species Reactivity Note: Bovine (Calf). May react with mouse, rat and human based on sequence homology. Reactivity with other species has not been determined. View All» Control: Bovine Retina tissue lysate. View All» Quality Assurance: Western Blot: View All» Purification Method: Purified by GST-depletion followed by Protein A View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q9Y5X4 View All» Gene Symbol:
  • ESCS

  • MGC49976

  • PNR

  • RNR

  • RP37

  • rd7
    View All» Alternate Names:
    • Nuclear receptor subfamily 2 group E member 3

    • Retina-specific nuclear receptor

    • nuclear receptor subfamily 2, group E, member 3

    • photoreceptor-specific nuclear receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Transcription factor that may have a role in the regulation of signaling pathways intrinsic to the photoreceptor cell function.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.DISEASE: Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Ref.5 Ref.6 Ref.7 Ref.8Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Ref.9SEQUENCE SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain. View All» Product Name: Anti-NR2E3 View All» Concentration: 1 mg/mL. View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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