货号：AB2295

品牌：Merck Millipore

规格：100Ug

目录价：￥4797.00

市场价格：￥4077.45

会员价格：￥3837.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho GluR4 (Ser842) Antibody | AB2295 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GluR4 when phosphorylated at Ser842. View All» Molecular Weight: ~101 kDa observed. An uncharacterized band may be visible at ~39 kDa in some lysates. View All» Epitope: Phosphorylated Ser842 View All» Immunogen: Linear peptide corresponding to rat GluR4 phosphorylated at Ser842. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. GluR4 is an ionotropic glutamate receptor encoded by the GRIA4 gene. Alternative splicings of this gene result in transcript variants encoding different isoforms, which are believed to vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. Direct phosphorylation of GluR4-containing receptors may regulate rapid excitatory synaptic transmission. In particular, phosphorylation of GluR4 at Serine 842 is both necessary and sufficient to deliver the receptor to the synapse and induce plasticity in early postnatal development. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology. View All» Control: Phosphatase treated and untreated rat cerebellum tissue lysates View All» Quality Assurance: Evaluated by Western Blot in phosphatase treated and untreated rat cerebellum tissue lysates.Western Blot Analysis: 0.5 µg/mL of this antibody detected GluR4 on 10 µg of phosphatase treated and untreated rat cerebellum tissue lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P19493 View All» Entrez Gene Number: NP_058959 View All» Gene Symbol:

• GRIA4

• GLUR4

• Gria4

• Glur4
  View All» Alternate Names:
  • glutamate receptor, AMPA 4

  • Glutamate receptor ionotropic, AMPA 4

  • AMPA-selective glutamate receptor 4

  • glutamate receptor 4

  • GluR-D

  • GluR-4

  • Glutamate receptor 4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.SUBUNIT STRUCTURE: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus. Isoform 3 interacts with PRKCABP.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Detected in cerebellum (at protein level).POST-TRANSLATIONAL MODIFICATION: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (by similarity).MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. View All» Product Name: Anti-phospho GluR4 (Ser842) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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