货号：AB2291

品牌：Merck Millipore

规格：

目录价：￥4399.00

市场价格：￥3739.15

会员价格：￥3519.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Choline acetylase Antibody | AB2291 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Choline acetylase at the C-terminus. View All» Molecular Weight: Three isoforms of Choline acetylase are produced by alternative splicing: Isoform M at 83 kDa, Isoform S at 74 kDa (observed), and Isoform R at 70 kDa. View All» Epitope: C-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of human Choline acetylase. View All» Background Information: Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetylase, aka choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human, rat, and mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 dilution of Anti-Choline acetylase antibody from a previous lot detected Choline acetylase in human cortex tissue. View All» Control: Human fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Choline acetylase in 10 µg of human fetal brain tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P28329 View All» Entrez Gene Number: NP_066264 View All» Gene Symbol:
  • CHAT

  • ChAT

  • CMS1A2

  • CHOACTase

  • CMS1A
    View All» Alternate Names:
    • choline acetyltransferase

    • acetyl CoA:choline O-acetyltransferase

    • Choline acetylase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer disease. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.SIZE: 748 amino acids; 82568 Da DISEASE: Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.SIMILARITY: Belongs to the carnitine/choline acetyltransferase family. View All» Product Name: Anti-Choline acetylase View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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