货号：AB2283

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tbr2 Antibody | AB2283 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Tbr2. View All» Molecular Weight: N/A View All» Epitope: Internal Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Tbr2. View All» Background Information: Tbr2 (a T-domain transcription factor) is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Trb2 has been shown to play a role in the development of the neocortex and functions in the differentiation pathway of radial glia to postmitotic projection neuron. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Proven to react with human and mouse. View All» Control: Human Brain Tissue View All» Quality Assurance: Evaluated by Immunohistochemistry of human brain tissue.Immunohistochemistry Analysis: A 1:300 dilution of Anti-Tbr2 antibody from a previous lot detected Tbr2 in mouse and human brain tissue. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O54839 View All» Entrez Gene Number: NP_034266 View All» Gene Symbol:
  • eomes

  • TBR2

  • eomesodermin, tbr1
    View All» Alternate Names:
    • eomesodermin (Xenopus laevis) homolog

    • eomesodermin homolog (Xenopus laevis)

    • t box, brain, 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Expressed in CD8+ T-cells.DEVELOPMENTAL STAGE: Originally expressed in the trophoectoderm of the blastocyst and later in the extra-embryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at E12.5 and E14.5 in the forebrain.INDUCTION: Up-regulated in CD8+ T-cells upon activation.DISRUPTION PHENOTYPE: Embryonic lethal due to peri-implantation defects. Mutant embryos arrest soon after implantation and fail to form organized embryonic or extraembryonic structures. Conditional mutants, with expression abrogated in the inner cell mass of embryos from early implantation stages onward, display gastrulation defects.SEQUENCE SIMLARITIES: Contains 1 T-box DNA-binding domain. View All» Product Name: Anti-Tbr2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Nucleus View All» Format: Affinity Purified View All» Host: Rabbit View All»
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