货号：AB2273

品牌：Merck Millipore

规格：100Ug

目录价：￥3863.00

市场价格：￥3283.55

会员价格：￥3090.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ZO-2 Antibody | AB2273 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ZO-2 at the PDZ3 domain. View All» Molecular Weight: Observed at ~160 kDa. View All» Epitope: PDZ3 domain View All» Immunogen: Linear peptide corresponding to the PDZ3 domain of human ZO-2. View All» Background Information: Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane associated guanylate kinase (MAGUK) family and include occludin and zona occludin family members ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with canine (dog) and chimpanzee based on 100% sequence homology. View All» Application Notes: Western Blot (SNAP ID) Analysis: 0.5 µg/mL from a previous lot detected ZO-2 on 10 µg of HEPG2 cell lysate.Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected ZO-2 in stomach cancer and colorectal carcinoma tissue. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected ZO-2 in 10 µg of HeLa cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UDY2 View All» Entrez Gene Number: NP_004808 View All» Gene Symbol:

• ZO-2

• ZO2

• TJP2
  View All» Alternate Names:
  • tight junction protein 2 (zona occludens 2)

  • tight junction protein ZO 2

  • tight junction protein ZO-2

  • Zona occludens protein 2

  • Friedreich ataxia region gene X104 (tight junction protein ZO-2)

  • Zonula occludens protein 2

  • Tight junction protein 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: Plays a role in tight junctions and adherens junctions.SUBUNIT STRUCTURE: Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB. SUBCELLULAR LOCATION: Cell junction › adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction › tight junction (By similarity). Nucleus (By similarity). Note: Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures (By similarity).TISSUE SPECIFICTY: This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.INVOLVEMENT IN DISEASE: Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Ref.26SEQUENCE SIMILARITIES: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 3 PDZ (DHR) domains.Contains 1 SH3 domain.SEQUENCE CAUTION: The sequence AAA61300.1 differs from that shown. Reason: Frameshift at positions 1086, 1092 and 1095. View All» Product Name: Anti-ZO-2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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