货号：AB2263

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEF2D Antibody | AB2263 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: Observed at ~ 54 kDa View All» Immunogen: KLH-conjugated linear peptide corresponding to human MEF2D. View All» Background Information: Myocyte-specific enhancer factor 2D is a transcriptional activator belonging to the MEF2 family. MEF2D has two domains of interest; a MADS-box domain, and a Mef2-type DNA-binding domain specifically binding to 5′-YTA[AT]4TAR-3′, the MEF2 element, which is observed in several gene types such as growth factor, muscle-specific, and stress-induced genes. MEF2D regulates various cellular processes including those within cardiac and skeletal muscle development, neuronal survival and differentiation, as well as cell growth, apoptosis and survival. MEF2D, along with ERK5, plays a vital role in neuronal survival by regulating the anti-apoptotic molecule, bcl-w. There are 6 known isoforms of MEF2D resulting from alternative splicing. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Pig

• Horse

• Rhesus Macaque

• Canine
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with porcine, equine, rhesus monkey, and canine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected MEF2D in normal human breast skin and inflammatory skin tissue. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected MEF2D on 10 µg of L6 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14814 View All» Entrez Gene Number: NP_005911 View All» Gene Symbol: MEF2D View All» Alternate Names:
  • myocyte enhancer factor 2D

  • MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)

  • MEF2D/DAZAP1 fusion

  • myocyte-specific enhancer factor 2D

  • myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). SUBUNIT STRUCTURE: Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A. SUBCELLULAR LOCATION: Nucleus. Note: Translocated by HDAC4 to nuclear dots.DEVELOPMENTAL STAGE: Present in myotubes and also in undifferentiated myoblasts.DOMAIN: The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. PTM: Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF. Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.Sumoylated on Lys-439 by SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3. Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity). SEQUENCE SIMILARITIES: Belongs to the MEF2 family.Contains 1 MADS-box domain.Contains 1 Mef2-type DNA-binding domain. View All» Product Name: Anti-MEF2D View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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