货号:AB2250
品牌:Merck Millipore
规格:
目录价:¥4383.00
市场价格:¥3725.55
会员价格:¥3506.40
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Description:
Anti-Eph A2/A3/A4/A5 Antibody, phospho (Tyr 596/602) | AB2250
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Specificity:
Cat. # AB2250 recognizes Eph A2/A3/A4/A5, phospho (Tyr 596/602)
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Molecular Weight:
~ 140 kDa
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Epitope:
Cytoplasmic Domain
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Immunogen:
Synthetic Linear Peptide.
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Modifications:
Phosphorylation
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Background Information:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
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Species Reactivity:
Human
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Species Reactivity Note:
Human. May react with mouse, rat, horse cow, chicken, monkey, dog and Xenopus based on sequence homology. Reactivity with other species has not been determined.
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Control:
A431 Cell lysate.
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Quality Assurance:
Routinely evaluated by western blot in A431 cell lysate
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Purification Method:
Immunoaffinity purified
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Presentation:
Purified in PBS with .07% Azide and 30% Glycerol.
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Storage Conditions:
Maintain at -20°C for up to 1 year from date of receipt.
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UniProt Number:
P29317
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Entrez Gene Number:
NP_004291.1
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Gene Symbol:
-
ECK
-
EphA2
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Alternate Names:
-
Tyrosine-protein kinase receptor ECK
-
Epithelial cell kinase
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
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Entrez Gene Summary:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. [provided by RefSeq]
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Product Name:
Anti-Eph A2/A3/A4/A5 Antibody, phospho (Tyr 596/602) | AB2250
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Concentration:
0.22 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 µL
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Target / Localization:
Plasma membrane
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Format:
Affinity Purified
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Host:
Rabbit
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