货号：AB2249

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CRIM1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2249 recognizes extracellular domain of CRIM1. View All» Molecular Weight: 100 kDa View All» Epitope: Extracellular Domain View All» Immunogen: Synthetic Linear Peptide View All» Background Information: Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180)families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM] View All» Species Reactivity: Mouse View All» Species Reactivity Note: Mouse. May react with rat, dog, chicken, horse, opposum and human based on sequence homology. Reactivity with other species has not been determined. View All» Control: Mouse heart lysate. View All» Quality Assurance: Routinely evaluated by western blot on mouse heart lysate. View All» Presentation: Purified in PBS with 0.05% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: Q9JLL0 View All» Entrez Gene Number: NM_016441.1 View All» Gene Symbol:

• CRIM-1

• MGC138194

• S52
  View All» Alternate Names:
  • Cysteine-rich repeat-containing protein S52

  • cysteine rich transmembrane BMP regulator 1 (chordin-like)

  • cysteine-rich motor neuron 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed Sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity). SUBUNIT: Interacts with BMP4 and BMP7 (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). SPECIFICITY: Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis. DEVELOPMENTAL STAGE: Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc. SIMILARITY: Contains 4 antistasin-like domains. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 6 VWFC domains. View All» Product Name: Anti-CRIM1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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