货号：AB2235

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Taurine Transporter Antibody | AB2235 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. AB2235 recognizes Taurine Transporter. View All» Molecular Weight: 65-70 kDa View All» Immunogen: Synthetic Linear Peptide. View All» Background Information: Taurine (2-aminoethane sulfonic acid), a beta-amino acid with a negatively charged sulfonic group is one of the most abundant amino acid in the brain. It is particularly enriched in excitable tissues, particularly those that generate oxidants. Taurine is produced by cysteine metabolism and obtained from diet as well. It is chemically inert molecule with a long turnover rate. It is not incorporated into proteins. It is thought to pay a major role in osmoregulation. It is also postulated to play a critical role in neurotransmission, neuromodulation, and membrane stabilization, neuronal differentiation, migration, synaptogenesis, and development. Taurine is transported to various target tissues by Na-dependent high affinity uptake system carried out in two distinct membrane transporter proteins: a high affinity (Km 40 uM) taurine transporter (TAU-1 or TAUT-1) and a beta-alanine and taurine transporter protein (Km 4.5 uM) known as TAUT-2 . Both TAUT-1/2 share significant sequence homology with the GABA and Glycine transporters that are characterized by the presence of 12 transmembrane domains. Taurine transporters are found in brain, retina and many other tissues. View All» Species Reactivity: Rat View All» Species Reactivity Note: Rat. May react with mouse based on sequence homology. View All» Control: Rat P1 brain. View All» Quality Assurance: Routinely tested on western blot. View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3 View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P31643 View All» Entrez Gene Number: NM_001134367.1 View All» Gene Symbol:

• MGC10619

• MGC131729

• TAUT 1
  View All» Alternate Names: solute carrier family 6 (neurotransmitter transporter, taurine), member 6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Required for the uptake of taurine. LOCATION: Membrane; Multi-pass membrane protein. SPECIFICITY: Brain and peripheral tissues. PTM: Down-regulated upon Ser-322 phosphorylation (By similarity). SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family. View All» Product Name: Anti-Taurine Transporter Antibody | AB2235 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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