货号：AB2226

品牌：Merck Millipore

规格：100Ug

目录价：￥4603.00

市场价格：￥3912.55

会员价格：￥3682.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MDGA1 Antibody | AB2226 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the MAM domain of MDGA1. View All» Molecular Weight: ~130kDa observed. UniProt describes 2 isoforms produced by alternative splicing at ~106 kDa (Isoform 1), ~107 kDa (Isoform 2). An uncharacterized band may be observed at ~48 kDa in some tissue lysates. View All» Epitope: MAM domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the MAM domain of MDGA1. View All» Background Information: Studies report that MDGA1 is a layer-specific marker and an area-specific marker, being expressed in layers 2/3 throughout the neocortex, but within the primary somatosensory area (S1), MDGA1 is also uniquely expressed in layers 4 and 6a. Comparisons with other markers, including cadherins, serotonin, cytochrome oxidase, RORß, and COUP-TF1, reveal unique features of patterned expression of MDGA1 within cortex and S1 barrels. Furthermore, during early stages of development, MDGA1 is expressed by Reelin- and Tbr1-positive Cajal–Retzius neurons that originate from multiple sources outside of neocortex and emigrate into it. At even earlier stages, MDGA1 is expressed by the earliest diencephalic and mesencephalic neurons, which appear to migrate from a MDGA1-positive domain of progenitors in the diencephalon and form a "preplate." These findings show that MDGA1 is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development. View All» Species Reactivity:

• Mouse

• Rat

• Bovine

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. Predicted to react with Bovine and Human based on 100% sequence homology. View All» Control: Untreated and PNGase F treated mouse P7 brain tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in untreated and PNGase F treated mouse P7 brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected MDGA1 in 5 µg of untreated and PNGase F treated mouse P7 brain tissue lysate. This antibody recognizes glycosolated (>160 kDa) (lane 1) and deglycosolated MDGA1 (lane 2). View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8NFP4 View All» Entrez Gene Number: NP_705691 View All» Gene Symbol:
  • MDGA1

  • MAMDC3
    View All» Alternate Names:
    • MAM domain-containing glycosylphosphatidylinositol anchor protein 1

    • GPI and MAM protein

    • GPIM

    • Glycosylphosphatidylinositol-MAM

    • MAM domain-containing protein 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Required for radial migration of cortical neurons in the superficial layer of the neocortex.SUBUNIT STRUCTURE: Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor. Note: Associated with lipid rafts.TISSUE SPECIFICITY: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues. View All» Product Name: Anti-MDGA1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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