货号：AB2219

品牌：Merck Millipore

规格：100Ug

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aquaporin 1 Antibody | AB2219 View All» Replaces: Cat. # AB3065 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Aquaporin 1. View All» Molecular Weight: 28 kDa View All» Immunogen: A 19 aa synthetic peptide from the cytosolic carboxyl terminal domain of the AQP1 (Lanahan et al. 1992; Deen et al. 1992; Moon et al. 1993; Patil et al. 1994) conjugated to KLH. This peptide contains most of the epitopes recognized by polyclonal antibodies against the whole protein (Smith & Agre 1991). The immunogen peptide is absolutely conserved in AQP1 from human, ovine, bovine, rat, and mouse. This peptide is available for blocking experiments (catalog number: AG307). View All» Background Information: Aquaporin 1 is a 28 kDa integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. View All» Species Reactivity: Rat View All» Application Notes: Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed tissue sections. Western Blotting: 1-10 μg/mL using Chemiluminescence technique. Immunoblots reveal two bands, a lower 28 kDa band corresponding to unglycosylated form and an upper high molecular 35-60 kDa glycosylated component (Denker et al. 1988; Smith & Agre 1991) We recommend the use of 0.5-1.0% milk in all primary/secondary antibody-enzyme conjugate incubations in order to suppress non-specific bands. ELISA: 0.5-1.0 μg/mL using 1 μg/mL control peptide (Catalog Number AG307)/well. Optimal working dilutions must be determined by end user. View All» Control: Routinely tested on adult rat heart lysate View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified in 0.1M Tris-Glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P29972 View All» Entrez Gene Number: NM_198098.1 View All» Gene Symbol:

• AQP1

• Aquaporin-CHIP

• MGC26324

• AQP-CHIP

• CO

• Aquaporin-1

• CHIP28

• AQP-1
  View All» Alternate Names: AQP1; CHIP; CHIP28 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. View All» UniProt Summary: FUNCTION: SwissProt: P29972 # Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.SIZE: 269 amino acids; 28526 Da SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.DOMAIN: SwissProt: P29972 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.MISCELLANEOUS: Pharmacologically inhibited by submillimolar concentrations of mercury. View All» Brand Family: Chemicon View All» Product Name: Anti-Aquaporin 1 Antibody | AB2219 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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