货号：AB1987

品牌：Merck Millipore

规格：50UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurofilament M (145 kDa) Antibody, C-terminus | AB1987 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Strong and specific staining for NF-M (145 kDa) View All» Molecular Weight: 145 kDa View All» Epitope: C-terminus View All» Immunogen: Recombinant fusion protein containing the C-terminal 168 amino acids of rat NF-M View All» Background Information: Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Pig

• Rat

• Quail

• Rabbit

• Reptile
  View All» Species Reactivity Note: Rat, human, mouse, pig, cow(bovine), chicken, quail, alligator and tortoise. View All» Application Notes: Immunohistochemistry: A 1:200 dilution of a previous lot was used in Immunohistochemistry.Staining is not affected by neurofilament phosphorylation. Optimal Staining With TE Buffer, pH 9.0, Epitope Retrieval: Human CerebellumImmunohistochemistry(paraffin): Optimal working dilutions must be determined by end user. View All» Control: Rat enteric neurons, rat spinal cord tissue Brain, Peripheral Nerve View All» Quality Assurance: Routinely evaluated by Western Blot on mouse brain lysates.Western Blot: 1:1000 dilution of this lot detected Neurofilament M on 10 μg of mouse brain lysates.. View All» Purification Method: Unpurified View All» Presentation: Neat rabbit antiserum containing no preservative. View All» Storage Conditions: Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P07197 View All» Entrez Gene Number: NM_001105541.1 View All» Gene Symbol:
  • NEFM

  • NF-M

  • NEF3

  • NFM
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P07197 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.SIZE: 916 amino acids; 102448 Da PTM: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.SIMILARITY: SwissProt: P07197 ## Belongs to the intermediate filament family. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurofilament M (145 kDa) Antibody, C-terminus | AB1987 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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      © Merck Millipore代理AB1987 Anti-Neurofilament M (145 kDa) Antibody, CT;抗神经丝M（145 kDa）抗体，CTstore at -20℃，产品报价联系微信jinshanbio