货号：AB19035

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 15 Antibody, C-terminus | AB19035 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ADAM15, cross reactivity with other ADAM family members untested. ADAM 15 is also called Kuzbanian in Drosophila Melanagaster. Peptide used is conserved in rat and mouse mapping to amino acids 851-864 for rat (gi38512117). BLAST analysis shows strong homology with human and canine as well but these species are untested. View All» Epitope: C-terminus View All» Immunogen: 13 amino acid synthetic peptide to the carboxyterminal region (RPAPPPPAASSLYL) View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 5% nonfat milk in PBS for blocking. Variable size on gel expected, as there are several processed forms of the protein. Immunocytochemistry: Immunohistochemistry: ELISA: IP: not tested FACS: Not Suitable Optimal working dilutions must be determined by end user. Application Notes Immunohistochemistry/ Immunocytochemistry: Tissues should be either fresh frozen or fixed in cold acetone. Tissues should be blocked in 10% Normal Goat serum in PBS. 10 antibody should be incubated in 10% Normal Goat Serum at a dilution of 1:200 and incubated 2 hours at room temperature or overnight at 40 . The antibody can be visualized by fluorescence. Recommended Positive Control Tissue: Lung extract or tissue View All» Applications Not Recommended: Flow Cytometry View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS with 1% BSA. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: Q13444 View All» Entrez Gene Number:
  • NM_003815.3

  • NM_207191.1

  • NM_207194.1

  • NM_207195.1

  • NM_207196.1

  • NM_207197.1
    View All» Gene Symbol:
    • ADAM15

    • MDC-15

    • metargidin

    • Metargidin

    • MDC15

    • EC 3.4.24.-
      View All» Alternate Names: Metargidin; MDC15 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q13444 # May be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 814 amino acids; 87717 Da SUBUNIT: Interacts with ITAGV-ITGB3 (vitronectin receptor), PACSIN3 and SNX9. PACSIN3 and SNX9 preferentially bind the precursor but not the processed form of ADAM15, suggesting that the interaction occurs in a secretory pathway compartment prior to the medial Golgi (By similarity). Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes.DOMAIN: SwissProt: Q13444 The cytoplasmic domain interacts with endophilin I and sorting nexin 9 (By similarity). & Desintegrin domain binds to integrin alphaV-beta3. & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase (By similarity). & Phosphorylation increases association with PTKs.SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain. View All» Brand Family: Chemicon View All» Product Name: Anti-ADAM 15 Antibody, C-terminus | AB19035 View All» Concentration: 0.19 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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