货号：AB19031

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 10 Antibody, C-terminus | AB19031 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ADAM 10 Kuzbainian, may cross react with other ADAM family members View All» Epitope: C-terminus View All» Immunogen: 13 amino acid, C-terminal peptide (QRPESYQMGHMRR) View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 5% nonfat milk in PBS for blocking. Variable size on gel expected, as there are several processed forms of the protein. Immunocytochemistry: Immunohistochemistry: ELISA: IP: not tested FACS: Not Suitable Optimal working dilutions must be determined by end user. Application Notes: Immunohistochemistry/ Immunocytochemistry: Tissues should be either fresh frozen or fixed in cold acetone. Tissues should be blocked in 10% Normal Goat serum in PBS. 10 antibody should be incubated in 10% Normal Goat Serum at a dilution of 1:200 and incubated 2 hours at room temperature or overnight at 40 . The antibody can be visualized by fluorescence.Recommended Positive Control Tissue: TestisExpected Staining: germ cells View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.01M Phosphate Buffer, 0.1% Sodium Azide, pH 7.1. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: O14672 View All» Entrez Gene Number: NM_001110.2 View All» Gene Symbol:

• ADAM10

• kuz

• MADM

• CDw156

• CD156c

• KUZ

• HsT18717

• kuzbanian

• EC 3.4.24.81
  View All» Alternate Names: Kuzbanian; Kuz; MADM View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. View All» UniProt Summary: FUNCTION: SwissProt: O14672 # Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).COFACTOR: Binds 1 zinc ion (By similarity).SIZE: 748 amino acids; 84142 Da SUBUNIT: Interacts with ephrin-A2 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Intracytoplasmic membrane; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.DOMAIN: SwissProt: O14672 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase (By similarity).SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain. View All» Brand Family: Chemicon View All» Product Name: Anti-ADAM 10 Antibody, C-terminus | AB19031 View All» Concentration: 1.1 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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