货号：AB19030

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 2 Antibody | AB19030 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ADAM-2 or Fertilin -betas involved in egg-sperm fusion. The antibody is specific to ADAM-2 cross reactivity with other family members is untested. View All» Immunogen: 13 amino acid peptide to the C-terminus of the protein (SEEQFESESESKD) View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 5% nonfat milk in PBS for blocking. Variable size on gel expected, as there are several processed forms of the protein. Immunocytochemistry: Immunohistochemistry: ELISA: IP: not tested FACS: Not Suitable Optimal working dilutions must be determined by end user. Application Notes Immunohistochemistry/ Immunocytochemistry: Tissues should be either fresh frozen or fixed in cold acetone. Tissues should be blocked in 10% Normal Goat serum in PBS. 10 antibody should be incubated in 10% Normal Goat Serum at a dilution of 1:200 and incubated 2 hours at room temperature or overnight at 40 . The antibody can be visualized by fluorescence. Recommended Positive Control Tissue: Sperm Expected Staining: spermatocytes and sperm View All» Applications Not Recommended: Flow Cytometry View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 1% BSA. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: Q99965 View All» Entrez Gene Number: NM_001464.3 View All» Gene Symbol:

• ADAM2

• PH30-beta

• CRYN2

• PH-30b

• PH-30

• PH30

• CRYN1

• CT15

• FTNB
  View All» Alternate Names: Fertilin beta View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. View All» UniProt Summary: FUNCTION: SwissProt: Q99965 # Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.SIZE: 735 amino acids; 82457 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.DOMAIN:SwissProt: Q99965 A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.PTM: The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain. MISCELLANEOUS: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene." View All» Brand Family: Chemicon View All» Product Name: Anti-ADAM 2 Antibody | AB19030 View All» Concentration: 0.317 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rabbit View All»
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