货号：AB1891

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop | AB1891 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for human C-X-X-X-C Chemokine Receptor 1 (CX3CR1) at the Extracellular loop. The sequence is identical to that of rat and differs from that of mouse by only one amino acid. View All» Epitope: extracellular loop View All» Immunogen: Synthetic peptide from the extracellular loop of human CX3CR1. View All» Background Information: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500 (THP cell lysate can be used as positive control and an approximately 50 kDa band can be detected) Immunohistochemistry in frozen sections Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide. View All» Storage Conditions: Store at 2-8°C for up to 12 months. View All» UniProt Number: P49238 View All» Entrez Gene Number: NM_001337.3 View All» Gene Symbol:

• CX3CR1

• CMKDR1

• GPR13

• CMK-BRL-1

• V28

• GPRV28

• CMKBRL1

• CCRL1

• CMKBLR1
  View All» Alternate Names: CX3CR1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: P49238 # Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV coreceptors than isoform 1.SIZE: 355 amino acids; 40396 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in lymphoid and neural tissues.SIMILARITY: SwissProt: P49238 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop | AB1891 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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