金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit for phosphorylated intracellular proteins Assay Length:4 hours 40 minutes (after plate preparation) Sample Type & Volume Required:Cell lysates (100 µL) Sufficient Materials:Kits available for two, five, or fifteen 96-well plates* Range:62.5 - 4,000 pg/mL Specificity:Please see the product datasheet Molecule Information: MKK3 Long Name: Mitogen-activated Protein Kinase Kinase 3 Aliases: MAP2K3; MEK3; PRKMK3 Entrez Gene IDs: 5606 (Human); 26397 (Mouse); 303200 (Rat) Background: MKK3/6 Mitogen-activated protein kinase kinase 3 (MKK3), also known as MEK3, and the closely related MKK6 are activated by proinflammatory cytokines and environmental stresses. Activation occurs through phosphorylation by several upstream MAPK kinase kinases, including ASK1 and TAK1. Both MKK3 and MKK6 are dual specificity protein kinases, phosphorylating and activating the p38 MAP kinases at Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr.