货号：AB1846

品牌：Merck Millipore

规格：100Ug

目录价：￥5160.00

市场价格：￥4386.00

会员价格：￥4128.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C-X-C Chemokine Receptor 4 Antibody, N-terminus | AB1846 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes CXCR4, N-terminus. View All» Molecular Weight: 40 kDa View All» Epitope: N-terminus View All» Immunogen: Amino-terminus peptide of human CXCR4 (Berson, 1996; Leotscher, 1994). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1-2 μg/mL. HeLa cell lysates can be used as positive control. The antibody should detect a band at 40 kDa. Immunocytochemistry: 10 μg/mL Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Control: Skin View All» Purification Method: Protein A purfied View All» Presentation: Purified IgG in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain 1 year at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P61073 View All» Entrez Gene Number:

• NM_001008540.1

• NM_003467.2
  View All» Gene Symbol:
  • CXCR4

  • WHIM

  • NPY3R

  • NPYY3R

  • FB22

  • LAP3

  • Fusin

  • CXCR-4

  • LCR1

  • NPYR

  • HM89

  • fusin

  • HSY3RR

  • CXC-R4

  • NPYY3

  • NPYRL

  • D2S201E

  • CD184

  • LESTR
    View All» Alternate Names: CD184; CXCR4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: SwissProt: P61073 # Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.SIZE: 352 amino acids; 39746 Da SUBUNIT: Interacts with HIV-1 surface protein gp120 and Tat.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.DOMAIN: SwissProt: P61073 The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.PTM: Sulfated.DISEASE: SwissProt: P61073 # Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.SIMILARITY: Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-C-X-C Chemokine Receptor 4 Antibody, N-terminus | AB1846 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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