货号：AB18001

品牌：Merck Millipore

规格：EA

目录价：￥3696.00

市场价格：￥3141.60

会员价格：￥2956.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Zebrafish Integrin alphaV Antibody | AB18001 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes zebrafish Integrin alphaV. View All» Molecular Weight: 180 kDa was observed; however, UniProtKB/TrEMBL entry Q3LTM3 has an expected MW of ~ 115 kDa. AlphaV-eGFP migrates at ~ 180 kDa under non-reducing conditions. View All» Epitope: 0 View All» Immunogen: Recombinant protein corresponding to zebrafish Integrin alphaV. View All» Background Information: Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of several alpha and beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets.The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Integrin alphaV is a type I membrane glycoptroein with no I (inserted) domain. The alphaV protein is post-translationally cleaved into a heavy and light chain, which is expressed on the cell surface as a disulfide linked polypeptide. View All» Species Reactivity: Zebrafish View All» Control: Zebrafish Integrin alphaV and beta3 transfected and nontransfected CHO cell lysates. View All» Quality Assurance: Evaluated by Western blot in zebrafish Integrin alphaV and beta3 transfected and nontransfected CHO cell lysates (non-reduced conditions).Western blot Analysis: 0.5 µg/mL of this antibody detected Integrin alphaV and beta3 in transfected and nontransfected CHO cell lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q3LTM3 View All» Entrez Gene Number: NP_001028893 View All» Gene Symbol:

• ITGA5

• CD49e

• FNRA

• VLA-5

• VLA5A
  View All» Alternate Names:
  • CD49e antigen

  • Integrin alpha-F

  • fibronectin receptor, alpha subunit

  • integrin alpha 5

  • very late activation protein 5, alpha subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein By similarity. SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family. View All» Product Name: Anti-Zebrafish Integrin alphaV View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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