货号：AB1778

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calbindin D-28K Antibody | AB1778 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Calbindin. Shows no cross-reactivity to calretinin by Western blot. The antibody produces specific staining of cerebellum Purkinje cells, molecular layer dendrites and axonal fibers, stains cell bodies and fibers in neuronal subpopulations. View All» Molecular Weight: 28 kDa View All» Immunogen: Recombinant mouse calbindin. View All» Background Information: Calbindin D-28k is a member of a large family of intracellular calcium-binding proteins of the EF-hand related to calmodulin and troponin-C. The biological roles of Calbindin D-28k include, calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to several disease states. Decline in calbindin D-28k in hippocampal dentate granule cells correlates with the kindling model for epilepsy. Calbindin D-28k immunoreactivity is specifically absent from neuronal poplulations lost early in ALS, while substantial loss of neurons which do contain the protein occur in patients with Huntington's disease. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse. Due to the homology of the protein it is expected to react with human, rat, and most species. View All» Application Notes: Immunocytochemistry: 1:1000-1:5000. See online protocols.Immunohistochemistry(paraffin):Optimal working dilutions and protocols must be determined by the end user. View All» Control: Mouse brain lysates and rat small intestine lysates. View All» Quality Assurance: Routinely evaluated by Western Blot on Mouse Brain lysates.Western Blot Analysis: 1:1000 dilution of this lot detected CALBINDIN on 10 μg of Mouse Brain lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in phosphate buffered saline containing an antibody that has been affinity preabsorbed against calretinin. Contains no preservative. View All» Storage Conditions: Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 uL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: P05937 View All» Entrez Gene Number: NM_004929.2 View All» Gene Symbol:
  • CAB27

  • CALB

  • D-28K
    View All» Alternate Names:
    • Calbindin D28

    • RTVL-H protein

    • Vitamin D-dependent calcium-binding protein, avian-type 3

    • calbindin

    • calbindin 1, (28kD)

    • calbindin 1, 28kDa
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. View All» UniProt Summary: FUNCTION: SwissProt: P05937 # Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.SIZE: 261 amino acids; 30025 Da SUBUNIT: Interacts with RANBP9.DOMAIN: SwissProt: P05937 This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.SIMILARITY: Belongs to the calbindin family. & Contains 5 EF-hand domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Calbindin D-28K Antibody | AB1778 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-152662.htm
        © Merck Millipore代理AB1778 CALBINDIN, RB X-100UL，产品报价联系微信jinshanbio