货号：AB1763

品牌：Merck Millipore

规格：EA

目录价：￥3430.00

市场价格：￥2915.50

会员价格：￥2744.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurogranin Antibody | AB1763 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neurogranin is a 78 amino acid neuron-specific substrate of protein kinase C that accumulates predominantly in dendritic shafts and spines of neurons. Immunoreactive neurogranin has been detected in many brain regions but is particularly abundant in the mammaliam forebrain. Immunostaining is completely abolished by pre-adsorption of the antibody with the immunogen peptide. View All» Immunogen: A synthetic peptide corresponding to amino acid residues 9-25 of the rat neurogranin protein. View All» Species Reactivity:

• Bovine

• Goat

• Human

• Rat
  View All» Application Notes: Western Blot: 1:1,000 (using ECL) Immunohistochemistry: 1:1,000 The antibody has been used successfully on paraformaldehyde-fixed cryostat or Vibratome sections. Immunoprecipitation: 1:250 on perchloric acid-treated brain homogenates using Protein A-Agarose to precipitate the immune complex. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q92686 View All» Entrez Gene Number: NM_006176.1 View All» Gene Symbol:
  • NRGN

  • neurogranin

  • Ng

  • Neurogranin

  • RC3

  • hng
    View All» Alternate Names: B50-immunoreactive C-Kinase Substrate View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. View All» UniProt Summary: FUNCTION: SwissProt: Q92686 # Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).SIZE: 78 amino acids; 7618 Da SIMILARITY: SwissProt: Q92686 ## Belongs to the neurogranin family. & Contains 1 collagen-like domain. & Contains 1 IQ domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurogranin Antibody | AB1763 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Rabbit View All»
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