Merck Millipore代理AB16942 Anti-DR5 Antibody, CT;store at +2℃ to +8℃

2025-07-24

货号:AB16942

品牌:Merck Millipore

规格:100Ug

目录价:¥5160.00

市场价格:¥4386.00

会员价格:¥4128.00

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-DR5 Antibody, C-terminus | AB16942 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2 or KILLER by several groups independently (Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. View All» Epitope: C-terminus View All» Immunogen: Polyclonal antibody raised against a peptide corresponding to amino acids 388-407 of human DR5 precursor (Pan et al. 1997; Sheridan et al. 1997). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:250 to 1:500 Whole cell lysate from HeLa or K562 cells can be used as a positive control . Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: O14763 View All» Entrez Gene Number:

  • NM_003842.3

  • NM_147187.1

    View All» Gene Symbol:
    • TNFRSF10B

    • KILLER/DR5

    • TRICKB

    • TRANCE-R

    • TRICK2

    • ZTNFR9

    • DR5

    • TRAIL-R2

    • TRICK2B

    • CD262

    • TRAILR2

    • KILLER

    • TRICK2A

      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. View All» UniProt Summary: FUNCTION: SwissProt: O14763 # Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.SIZE: 440 amino acids; 47850 Da SUBUNIT: Homotrimer. Can interact with TRADD and RIP.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.DISEASE:SwissProt: O14763 # Defects in TNFRSF10B may be a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].SIMILARITY: SwissProt: O14763 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-DR5 Antibody, C-terminus | AB16942 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»

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