货号：AB16518

品牌：Merck Millipore

规格：100Ug

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SODD Antibody, N-terminus | AB16518 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5 and DR6 were recently indentified. The cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of the these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains (Jiang et al. 1999). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines. View All» Epitope: N-terminus View All» Immunogen: Rabbit anti-SODD (N-terminal) polyclonal antibody was raised against a peptide corresponding to amino acids 2 to 16 of human SODD (Jiang et al. 1999). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:500 to 1:2000 HeLa and THP-1 whole cell lysate can be used as positive control and an approximately 60 kDa band can be detected. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: O95429 View All» Entrez Gene Number: NM_004874.2 View All» Gene Symbol:
  • BAG4

  • SODD

  • Bag-4

  • BAG-4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. View All» UniProt Summary: FUNCTION: SwissProt: O95429 # Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.SIZE: 457 amino acids; 49594 Da SUBUNIT: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: O95429 ## Contains 1 BAG domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SODD Antibody, N-terminus | AB16518 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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